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基本信息

英文名稱(chēng)	Tazemetostat (Synonyms: EPZ-6438; E-7438; E7438)
中文名稱(chēng)	Tazemetostat (EPZ-6438; E-7438) \| 他澤司他
CAS號(hào)	1403254-99-8
分子式	C34H44N4O4
分子量	572.74
外觀	Off-white to light yellow powder
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Tazemetostat, also known as EPZ-6438 and E7438, is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation.
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Tazemetostat (EPZ-6438; E-7438) | 他澤司他

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Tazemetostat (EPZ-6438; E-7438) | 他澤司他

Tazemetostat (Synonyms: EPZ-6438; E-7438; E7438)

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