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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專(zhuān)享價(jià)	數(shù)量
20 mg	In-stock	￥350.00	登錄后可見(jiàn)	- +
50 mg	3-5days	￥600.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專(zhuān)享價(jià)

數(shù)量

20 mg

In-stock

￥350.00

登錄后可見(jiàn)

- +

50 mg

3-5days

￥600.00

登錄后可見(jiàn)

- +

基本信息

英文名稱(chēng)	Adezmapimod (Synonyms: SB 203580; RWJ 64809;PB 203580)
中文名稱(chēng)	Adezmapimod \|SB 203580 \| RWJ 64809 \| PB 203580
CAS號(hào)	152121-47-6
分子式	C21H16FN3OS
分子量	377.43
外觀(guān)	White to light yellow
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.

相關(guān)文獻(xiàn)

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase.

PMID: 10702313 DOI: 10.1074/jbc.275.10.7395

PMID: 24216180 PMCID: PMC3946852 DOI: 10.1016/j.molonc.2013.10.003

PMID: 10998351 PMCID: PMC1221339 DOI: 10.1042/0264-6021:3510095

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