Quizartinib (formerly also know as AC-220; AC-010220, Vanflyta) is a novel, potent, 2nd-generation, and orally bioavailable FLT3 tyrosine kinase inhibitor for Flt3 (ITD/WT) with potential anticancer activity.With IC50s of 1.1 nM and 4.2 nM, respectively, it inhibits FLT3 in MV4-11 and RS4EL11 cells. With respect to KIT, PDGFRα, PDGFRβ, RET, and CSF-1R, it demonstrates a ten-fold greater selectivity. Currently, Daiichi Sankyo is developing quizartinib to treat acute myeloid leukemia. Quizartinib (Vanflyta) was approved in 2023 by FDA for treating AML.
Keywords: buy Quizartinib (AC220) | Quizartinib (AC220) ic50 | Quizartinib (AC220) price | Quizartinib (AC220) cost | Quizartinib (AC220) solubility dmso | Quizartinib (AC220) purchase | Quizartinib (AC220) manufacturer | Quizartinib (AC220) research buy | Quizartinib (AC220) order | Quizartinib (AC220) mouse | Quizartinib (AC220) chemical structure | Quizartinib (AC220) mw | Quizartinib (AC220) molecular weight | Quizartinib (AC220) datasheet | Quizartinib (AC220) supplier | Quizartinib (AC220) in vitro | Quizartinib (AC220) cell line | Quizartinib (AC220) concentration | Quizartinib (AC220) nmr